Gynostemma Extract mainly contains saponins, and the highest content is leaves, followed by stems and aerial parts. Its basic structure is a dammarane type tetracyclic triterpene. Also included are flavonoid glycosides, sugars, sterols, organic acids, pigments, cellulose, vegetable proteins, starches, and the like.
Immunomodulatory effect
(1) Gynostemma extract can increase the spleen weight of mice. Lymphocytosis increases around the central spleen and increases the conversion of T lymphocytes. Mononuclear cell proliferation, active phagocytosis.
(2) Gynostemma polysaccharide significantly enhances the phagocytosis of peritoneal macrophages.
(3) Regulating DNA action Small doses of Gynostemma pentaphyllum can promote lymphocyte DNA synthesis, while large doses have opposite inhibition.
Anti-aging effect
Gynostemma total saponins can significantly prolong the average lifespan of Drosophila, which can significantly increase SOD activity in housefly, mouse brain and liver, and significantly reduce MDA content. Gynostemma can reduce the content of lipid peroxide and serum lipofuscin in serum, heart, brain and liver of aged rats. Gynostemma polysaccharide also has the effect of delaying aging.
Anti-tumor effect
Gynostemma saponins have significant inhibitory effects on a variety of tumor cells
Protective effect on myocardial infarction and myocardial ischemia
In vivo and in vitro experiments have confirmed that injection of Gynostemma pentaphyllum has obvious protective effects on myocardial infarction and myocardial ischemia-reperfusion injury. Reduce the scope of myocardial infarction, inhibit the increase of free fatty acids in the blood after myocardial infarction, reduce the MDA content in rat myocardium, protect myocardial SOD activity, and inhibit the increase of serum lactate dehydrogenase.
Enhance physical strength and anti-fatigue
Gynostemma water extract, saponin and total sputum test proved that it can prolong the swimming time, climbing time and load swimming time of mice. 200mg/kg of Gynostemma pentaphyllum extract for 14 days can maintain high blood sugar levels and reduce muscle glycogen loss in long-term swimming rats, which may be an important reason for Gynostemma resistance to fatigue.
Enhanced sexual function
The gavage of Gynostemma pentaphyllum extract can significantly increase the uterus weight of testes and prostate and female mice in male mice compared with the control group, indicating that Gynostemma pentaphyllum has male estrogen-like effects.
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